People

Leadership and faculty members of CeMiSt
 Leadership and faculty members
   

Lone Gram, Professor and Center Leader

What I do: I am the leader of the CeMiSt Center. I am, together with the Center coordinator, the contact person and responsible for budget and the overall scientific progress. I supervise PhD students, mentor postdocs and assistant professors, and look for additional funding. I am also head of the Section for Microbial and Chemical Ecology at Department of Biotechnology and Bioengineering. My science evolves around bacterial ecophysiology and biotechnology with a focus on marine bacterial I am a member of the Research Council for Natural Science.

Where to find me: office 140, building 221

How to reach me: gram@bio.dtu.dk

 

Dario Vazquez Albacete, Center Coordinator

What I do: I am the center coordinator of CeMiSt. My role is to assist the center leader to ensure the execution of the research plan and well functioning of the center. I keep finances updated, carry out science communication actions through our media channels, organize scientific conferences and promotion events as well as assisting in the process of hiring new researchers. I am also the correspondent anchor at CeMiSt and the link between our host institution, DTU Bioengineering, and the Center.

Where to find me: office 138, building 221

How to reach me: davaa@dtu.dk

     
 

Ling Ding, Associate professor 

What I do: Research interests: 1. Natural product analysis and isolation; 2. Biosynthetic investigation of unusual secondary metabolites. ORCID: 0000-0001-8979-3104
ResearchGate: https://www.researchgate.net/profile/Ling_Ding6

Where to find me: office room 122, building 221

How to reach me: lidi@dtu.dk

   

Tilmann Weber, Professor

What I do: My group is interested in developing computational tools, such as antiSMASH, to mine the genomes of microorganisms for the presence of secondary metabolite biosynthetic gene clusters that code for the production of these complex metabolites and use these data to engineer the production of these compounds.
Within CeMiSt, we are mainly involved in adapting and optimizing our tools for the bioinformatics tasks within the center.

Where to find me: Kemitorvet building 220, room 327D

How to reach me: tiwe@biosustain.dtu.dk, tel. +45 24 89 61 32

     

Mikkel Bentzon-Tilia, Assistant professor

What I do: The overarching theme of my research activities is how microbes act and interact in their environment, and how we can investigate and utilize their behavior by analyzing the molecules they comprise and produce. With a special focus on marine environments, I am currently investigating to what extent microbial community members, which are proficient producers of bioactive secondary metabolites, are capable of shaping microbial communities.

Where to find me: Søltofts Plads, Bygning 221, room 152, 2800 Kgs. Lyngby

How to reach me: mibti@bio.dtu.dk

 

Akos Kovacs, Professor

What I do: I study bacterial interaction and evolution, and the underlying phenotypic and genetic changes. My group aims to reveal the ecology of Bacilli, understand their social interactions during biofilm development and adaptation in the presence of other microorganisms, including soil derived bacteria and fungi, in which niche secondary metabolites are expected to have a great impact.

Where to find me: office 158, building 221

How to reach me: atkovacs@dtu.dk


     
 

Lars Jelsbak, Professor MSO

 

What I do: My group works at the interface of microbial genomics, ecology, and functional genetics to understand, engineer, and control bacterial systems that relate to medicine, sustainable agriculture, and biotechnology. Our work is largely centered on Pseudomonas species
Our activities in CeMiSt revolves around understanding the role of the genetic and chemical diversity of Pseudomonas species in soils. We are currently developing/applying synthetic biology tools to be able to manipulate secondary metabolite production in different Pseudomonas species, and work with chemists to detect and quantify these molecules

Where to find me: Building 221, 260

How to reach me: lj@bio.dtu.dk

   

Mikael Lenz Strube, Associate professor

What I do: I work on bioinformatical analysis of metagenomic and metataxonomic data derived from all microbiological niches.

Where to find me: Building 202, room 137, DTU

How to reach me: milst@bio.dtu.dk

     
 

Rasmus John Normand Frandsen, Associate professor

What I do:

•    Elucidation of natural biosynthetic pathways in filamentous fungi and insects
•    Extensive experience with plant pathogen fungi belonging to the Fusaria genus
•    Expert on molecular biology and genome engineering in fungi
•    Production of small molecules in (heterologous expression/production)

In connection with the CeMiSt Center, my work will focus on understanding various fungi’s production of small molecules as a response to the continuously changing environment and microbiota in the ecosystem that they naturally inhabit. This work will entail: 1) Construction of fungi with build-in reporter systems that will allow us to visually track the individual cell’s location in a given sample (e.g. apples) and their production of various metabolites. 2) Elucidate the function of the chemical arsenal that the fungi possess, by creating fungi that overproduce or do not produce the given compounds, and then analyze their fitness and impact in the analyzed ecosystem.
My interest spans from the molecular level (DNA, proteins and small molecules) to the entire ecosystem, and both at the minute to minute as well as at the evolutionary timescale.

Where to find me: Building 223, Room 223

How to reach me:rasf@dtu.dk


   

Jens Frisvad, Professor

What I do: Biological and chemical diversity of the genera Aspergillus, Penicillium and Talaromyces. Prevention of growth and mycotoxin production, and biotechnological exploitation of filamentous fungi. Key findings: Fungal species are clear-cut classes, are specifically associated to different substrates and produce species specific profiles of secondary metabolites.

Where to find me: Building 221, 124

How to reach me: jcf@bio.dtu.dk


     
 

Charlotte Held Gotfredsen, Associate professor

What I do: I am Head of the NMR Center • DTU, a newly established DTU campus core infrastructure. My research group has special interest in the field of NMR spectroscopy at the interface between chemistry and biology as a tool to acquire structural knowledge and compound identification and tracking. In CeMiSt we will be working and using the NMR and chemistry competences with focus on interdisciplinarity, exploring NMR in the study of secondary metabolites and their evolutionary role.

Where to find me: DTU Chemistry, Building 207 room 210

How to reach me: chg@kemi.dtu.dk


   

Thomas Ostenfeld Larsen, Professor

What I do: I study and teach microbial natural product chemistry, and am in particular interested in discovery of novel of bioactive compounds and their biosynthetic pathways. The current activities in my research group are focused on genomics driven discovery and engineering of cryptic secondary metabolite biosynthetic pathways in filamentous fungi, as well as chemical ecology and toxicity of natural products from marine bacteria and fish killing microalgae. I’m also involved in activities aiming at commercialization of novel fungal pigments and is a member of the executive board of CeMiSt.

Where to find me: Building 221, 126

How to reach me: tol@bio.dtu.dk


     
 

Aaron John Christian Andersen, Platform manager

What I do: As the manager of the Metabolomics Core at the Department of Bioengineering I work closely with CeMiSt to help facilitate the analysis of secondary metabolites found within complex biological systems. With a background in marine natural products chemistry and metabolomics, I have undertaken research on many different marine organisms, from antibiotic producing arctic marine invertebrates to fish killing microalgae with global distributions. These varying biological substrates, as well as their complex and unique molecular profiles, has given me a keen interest in secondary metabolite discovery and understanding the role of these metabolites within the environment. Using the latest techniques and instrumentation in mass spectrometry coupled to chromatography, I am interested producing high quality metabolomics data and using this to investigate metabolites in biological systems

Where to find me: Building 221, 118

How to reach me: ajca@dtu.dk


   

Eva Sonneschein, Senior researcher

What I do: I am a marine microbiologist investigating how microorganisms interact and communicate in beneficial and detrimental ways on a microscopic scale. I study bacteria and microalgae and their interaction pathways from their genes to their environmental effect and distribution in the laboratory and in silico. My aim is to predict how chemical communication controls and is controlled by the environment.

Where to find me: Building 221, 152

How to reach me: evaso@bio.dtu.dk


 

PhD students and postdoctoral researchers

   
 

Pernille Kjersgaard Bech, PhD student


What I do: I am a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering. I have a background within bacteriology and microbial molecular ecology with a special interest in the marine environments. The aim of my PhD project is to determine the relationship between microbial species diversity and the genetic diversity of gene clusters involved in microbial secondary metabolite biosynthesis. My work will include bioinformatic tools such as amplicon sequencing and metagenomic analyses of microbial communities across different ecological niches in both marine and terrestrial environments.

Where to find me: Building 221, room 146

How to reach me: perbec@dtu.dk

   

Morten Lindqvist Hansen, PhD student

What I do: The main part of my research is to employ tools from the synthetic biology toolbox to perform genetic engineering in natural soil bacteria with the aim to manipulate and study the production of secondary metabolites. Secondly, I intend on aiding in the development of an in vitro soil system to facilitate the study of advanced microbial communities and inter-species interactions. I am currently attempting to develop and adapt a CRISPR/Cas9-assisted recombineering tool for streamlined mutagenesis in natural soil microbes with a particular focus on secondary metabolite producing bacteria of the Pseudomonas group.

Where to find me: Building 221, room 258

How to reach me: morlin@dtu.dk

     
 

Heiko T. Kiesewalter, PhD student

Heiko T. Kiesewalter

What I do: I am a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering. I have a background within bacteriology, biotechnology and biogeosciences with a special interest in the terrestrial environments. The aim of my PhD project is to determine the impact of secondary metabolites on the ecology of Bacillus subtilis. My work will include comparative genomics, secondary metabolite profiling, bioactivity screens and genetic modification to understand the abundance, the biofilm formation ability and biocontrol properties of B. subtilis strains, isolated from diverse soil ecosystems. Subsequently, the real ecological importance of secondary metabolites produced by B. subtilis will be revealed by microcosm experiments.

Where to find me: Building 221, room 156

How to reach me: heikok@dtu.dk

   

Carlos Neftaly Lozano Andrade, PhD student

 

What I doI am a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering. I have a background within bacteriology and microbial ecology. My PhD project will examine the impact of secondary metabolites on the ecology and evolution of Bacillus subtilis in soil derived communities. My work will include secondary metabolite profiling on soil, genetic modification, and transposons insertion sequencing analysis to understand the function of secondary metabolite on bacterial physiology and development in the soil

Where to find me: Building 221, room 156

How to reach me: cnla@dtu.dk


     
 

Nathalie Nina Suhr Eiris Henriksen, PhD student

 

What I do: I am a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering. I have a background within microbial evolution and marine microbiology. My PhD project focuses on the effects on microbial diversity and functionality of marine microbial communities as a function of key secondary metabolites. My work includes the development and use of marine model systems, that allow studies of the evolutionary effects of secondary metabolites on microbial communities.

Where to find me: Building 221, room 146

How to reach me: nasuh@dtu.dk

   

Sidsel Ettrup Clemmensen, PhD student

 

What I do: As a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering, my aim is to investigate the role of secondary metabolites in the structure and development of microbial communities of apples.
The focus of my PhD will be the filamentous fungus Penicillium expansum, as it is often a dominant player in the apple microbial community and the causing agent of blue mold decay of apples.
My work includes characterization of the natural community, the development of a toolbox for genetic engineering of P. expansum, and to generate mutant strains for a mock community to investigate the role of the secondary metabolites


Where to find me: Building 223, room 221

How to reach me: sett@dtu.dk

     
 

Mathies Brinks Sørensen, PhD student

 

What I do: I am a PhD student at the Center for Microbial Secondary Metabolites at DTU Bioengineering and DTU chemistry. My background is a mix of biotechnology, NMR and statistical modelling with a heavy focus on biostatistics.  The goal of my PhD project is to investigate the NMR profile of different microbial environments, analyzing the composition of the different environments when being subjugation to different impacts. Furthermore, working with orthogonal data, the other goal is to generate a model for each of the different microbial systems, explaining the various NMR profiles in a multivariate setting and predicting the outcome over time. The work would include proton and carbon-based NMR in 1d and 2d for recording the spectra. The modelling work would include chemometrics and various statistical models ranging from simple partial least squares regression to more demanding mixed effect time series models.

Where to find me: Building 207, Room 207

How to reach me: mabso@kemi.dtu.dk

   
     
 

Mario Wibowo, Postdoc

What I do: What I do: I am a postdoctoral researcher at CeMiSt. My research interest revolves around natural products chemistry (secondary metabolites dereplication,  isolation, and structure elucidation). In CeMiSt, I am working on the detection of microbial natural products in natural and engineered systems.

Where to find me: Building 221, room 128

How to reach me: mawibo@dtu.dk

   

Kresten Jon Korup Kromphardt, Postdoc

 

What I do: My research is focused on unveiling the interactions of microbes on decaying apples. The microbes of interest in my project are primarily fungi as these produce a plethora of enzymes to decompose the apple as well as secondary metabolites, which may play a role in the colonization of the apple by communication with or warfare against other microbes growing on the apple. Assessment of the role of individual metabolites and how the presence or absence of a given metabolite may influence the community are pivotal in understanding the community. Along with studying the natural system of apple decomposition I also work with creation of a mock apple community by inoculation of healthy apples with our microbes of interest.

Where to find me: Building 223, Room 230

How to reach me: krjko@dtu.dk

     
 

Anna Dragos, Postdoc

 

What I do: I study the role of bacterial viruses, or phages in horizontal transfer of biosynthetic gene clusters (BGCs) among bacteria. I am also interested in evolutionary role of these large BGCs in size-constrained phage genomes. Finally, I investigate how chromosome-attached phages (prophages) influence the response of their bacterial hosts to specialized metabolites present in the environment. My favorite microbe is Bacillus subtilis and my research toolbox contains classical bacteriology/virology methods, molecular genetics, cell imaging and bioinformatics.

Where to find me: Building 221, Room 164

How to reach me: adragos@dtu.dk

   

 

Research assistants

   

Laura Louise Lindqvist, Research Assistant

 

What I do: I am a research assistant at the Center for Microbial Secondary Metabolites at DTU Bioengineering. I have a background in molecular biology and microbiology. My work is centered on constructing genetic knock-outs in Roseobacters to be used for studying microbial communities and the function of secondary metabolites. 

Where to find me: Building 221, Room 146

How to reach me: lloli@dtu.dk